This research work was an attempt to increase the solubility dissolution rate of rifampicin by solid dispersion as the poor solubility of drug substances in water and their low dissolution rate in aqueous G.I.T. fluid often leads to insufficient bioavailability, this low bioavailability leads to less therapeutic effect of particular drug. Rifampicin belongs to BCS class II, which is slightly soluble in water. The carrier or hydrotropic agent used here for preparation of solid dispersion is urea. The hydrotrophy method or solvent evaporation method is very economic, easy and less time consuming and also less harmful as distilled water is used for preparation of solid dispersion. Evaluation of prepared solid dispersion reveals that solubility profile of rifampicin has increased to some extent and hence, bioavailability also increased.
Loading....